Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina
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چکیده
منابع مشابه
Immobilization of Saccharomyces cerevisiae cystathionine gamma-lyase and application of the product to cystathionine synthesis.
Cystathionine gamma-lyase of Saccharomyces cerevisiae was immobilized to aminohexyl-Sepharose through the cofactor pyridoxal 5'-phosphate and was characterized with respect to its cystathionine gamma-synthase activity. The immobilized product was so stable that it repeatedly catalyzed as many as five cycles of the reaction without losing activity.
متن کاملDomain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases
Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. Although the pathway itself is well conserved among eukaryotes, properties of eukaryotic CBS enzymes vary greatly. Here we present a side-by-side biochemical and biophysical co...
متن کاملDuodenal acidification stimulates gastric H2S release through upregulating mRNA expression of cystathionine gamma lyase
Introduction: It has been reported the alkaline response of pancreas to duodenal acidification is partly mediated through duodenal release of H2S, but till now the effect of duodenal acidification on gastric H2S release has not been investigated. Therefore, the present study designed to evaluate the effects of duodenal acidification on gastric H2S release and level of mRNA expression of cys...
متن کاملThe expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts
Hydrogen sulfide (H2S), generated in the osteoblasts predominantly via cystathionine-γ-lyase (CSE), is bone protective. Previous studies suggested that the onset of bone loss due to estrogen deficiency is associated to decreased levels of H2S and blunted gene expression of CSE. However, there are still a lot of unknowns on how H2S levels influence bone cells function. The present study aims to ...
متن کاملL-cystathionine in human brain.
During the course of the study of the distribution of N-acetylaspartic acid in brains of different species (1, 2), protein-free extracts of brain tissues were analyzed specifically for the aspartic acid derivative. In pursuing these investigations further, a survey was made by ion exchange chromatography of the concentration of all of the free acidic and neutral amino acids of the brain tissues...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2019
ISSN: 0014-4835
DOI: 10.1016/j.exer.2019.01.007